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Weight Loss May Be Associated With Improvements In Hot Flushes In Overweight and Obese Women

Among overweight and obese women with bothersome hot flushes during menopause, an intensive weight loss intervention program may lead to improvements in flushing, according to a report in the July 12 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

“Hot flushes are among the most common concerns of women during menopause and persist for five or more years past menopause in as many as one-third of women,” the authors write as background to the article. “In multiple observational studies, women with a higher body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) have reported more frequent or severe hot flushes compared with women with a lower BMI.”

Alison J. Huang, M.D., from the University of California, San Francisco, and colleagues in a six-month randomized controlled trial, used self-administered questionnaires to assess bothersome hot flushes. The authors studied 338 women (average age 53) who were overweight or obese and had urinary incontinence. Of the participants, 226 were randomized to the intensive weight loss intervention and 112 were randomized to the control group. Approximately half of the women in each group reported being at least slightly bothered by flushing at the beginning of the study. Compared to the control individuals, women randomized to the intervention group reported slightly greater physical activity at baseline but the two study groups did not differ significantly with regard to other characteristics, including flushing.

Women in the intensive intervention group were assigned to a lifestyle and behavior change program designed to produce an average loss of 7 to 9 percent of initial body weight by six months. This included weekly one-hour group sessions with experts in nutrition, exercise and behavior change during which participants were encouraged to increase physical activity to at least 200 minutes per week using brisk walking or activities of a similar intensity. Women were also instructed to follow a reduced-calorie diet (1,200-1,500 calories) and were offered sample meal plans providing appropriate food selections as well as meal-replacement products.

According to the authors, in analyses of all women reporting bothersome hot flushes at the initial stages, decreases in weight, BMI and abdominal circumference were each associated with improvement in self-reported hot flushes during six months. However, there were no significant associations between changes in physical activity, calorie intake, blood pressure or overall self-reported physical and mental functioning and change in bothersome flushing.

Additionally, “among women who were at least slightly bothered by flushing at baseline, the intensive lifestyle intervention was associated with significantly greater decreases in weight, body mass index, abdominal circumference and systolic and diastolic blood pressure relative to the control group,” the authors write. “No statistically significant effect of the intervention on self-reported physical activity, total calorie intake or overall physical or mental functioning was observed.”

“Our findings indicate that women who are overweight or obese and experience bothersome hot flushes may also experience improvement in these symptoms after pursuing behavioral weight loss strategies; however, improvements in weight or body composition may not be the only mediators of this effect,” the authors conclude.

Meals As Medicine: Anti-Obesity Effects Of Soy In Rat Model Of Menopause

Research presented at the Annual Meeting of the Society for the Study of Ingestive Behavior, finds that a diet rich in soy prevents weight gain in post-menopausal female rats.

Previous research suggests that reduced levels of the hormone estrogen during menopause are responsible for the increased body weight and abdominal fat often experienced by postmenopausal women. However, while estrogen replacement therapies can reduce weight gain, they also have unwelcome side effects, prompting a search for alternative methods of treatment.

Soy naturally contains estrogen-like compounds called phytoestrogens, and so dietary soy may provide an alternative to typical estrogen replacement therapies.

Michelle Murphy from the Monell Chemical Senses Center found decreased body weight and increased energy expenditure in post-menopausal rats after adding soy phytoestrogens to their regular diet. She comments, “These results have implications for the development of alternative natural treatments for obesity in post-menopausal women.”

The results of this study highlight the need for further research into the actions of phytoestrogens on food intake in humans to determine the more long-term effects of consuming a soy-rich diet.

“In this world of an ever-increasing obesity epidemic, finding natural dietary solutions and treatments to combat obesity are of the utmost importance both to worldwide health and economy,” says Murphy.

The lead author was Michelle Murphy of the Monell Chemical Senses Center, Philadelphia, PA, USA. Co-authors were MR Rosazza, DR Reed and MG Tordoff also of the Monell Chemical Senses Center, Philadelphia, PA, USA.

Women Hit By Midlife Challenges

It is dubbed the midlife crisis, middle age spread era, the climacteric, the change of life or simply “the change” and has even inspired a play, Menopause the Musical.

The variety of nicknames for menopause reflects the diversity of ways in which women are affected during this major turning point in their life.

Most women have a relatively easy time making their way through menopause, some completely breeze through without a whimper but there are the unfortunate ones who are hit hard by unrelenting symptoms.

Internationally renowned gynaecologist Dr Elizabeth Farrell, who specialises in menopause and is a founding Board member of the Jean Hailes Foundation for Women’s Health in Victoria, said that the majority of women would have mild to moderate symptoms and could probably manage without any added therapy.

About 20 per cent of women would experience no symptoms.

“Their periods will stop and they will feel fit and healthy and nothing will be different,” she said.

Another 20 per cent would have severe symptoms which impacted on their quality of life and were the women who really needed to have treatment.

For women in their perimenopausal and early-postmenopausal years, the use of hormone replacement therapy was considered safe.

“But it is contrary to people’s memories,” Dr Farrell said.

“They still have the study published in 2002 in the forefront of their brains.”

That study, the Women’s Health Initiative, reported a slightly increased risk of stroke, heart disease and thrombosis in women on long-term combined oestrogen and progesterone HRT.

Dr Farrell said that for women going through menopausal symptoms, the use of HRT was acceptable if they had no heart disease risks and were fit and healthy.

Although the WHI study showed that in those women taking oestrogen and progesterone, there was a small increase in the risk of breast cancer after five years of use, Dr Farrell said most of those women had been on HRT before the study. This was because the average age of participants was 63 years.

Women on oestrogen alone had no increased risk of breast cancer after seven years. In community studies, including the Nurses Health Study, there was no increased risk in women on oestrogen alone until after 15-20 years, Dr Farrell said.

Dr Farrell, who is president of the Australasian Menopause Society and also the Asia Pacific Menopause Federation, said it was worth having a medical check to rule out other possible causes – such as high blood pressure and hyper-thyroidism – for hot flashes and sweats.

Although venlafaxine (an antidepressant) could be used to alleviate hot flashes and sweats, it also caused them in about 20-30 per cent of women.

Evidence suggested that women who were suffering from a dry vagina could first try lubricants but if these were not sufficient, they could use one of the vaginal oestrogen products fairly safely, Dr Farrell said.

These included oestriol vaginal creams or pessaries which should be used only about twice a week in the longer term.

Women who wanted to navigate menopause naturally, without any medication, could take certain steps, Dr Farrell said.

Anxiety and stress can be triggers for flushes and sweats. “Some of the things that are recommended are meditation and yoga,” she said.

“Acupuncture hasn’t been shown to be effective but hypnosis has been shown to be effective in some women and things like paced respiration, doing the deep breathing like you do in labour, and biofeedback programs can be helpful.”

Another hazard was a teenage daughter dealing with puberty at the same time her mother was going through menopause. “Sometimes a little bit of family counselling can help,” Dr Farrell said.

Gynaecologist Dr Margaret Smith, who established the first menopause clinic in WA and is a foundation member of the Australasian Menopause Society, said that hormone replacement therapy was now called hormone therapy because the aim was not to attain premenopausal levels of oestrogen but to give small amounts for a short time to ease the symptoms of menopause, such as hot flashes, without causing breast soreness.

But Dr Smith said while some effects of oestrogen deficiency could be relieved, others could last for years. These included loss of bone density, which could lead to osteoporosis, and lack of oestrogens in the vagina which can lead to painful intercourse and urinary tract infection.

Hormone therapy could be given locally into the vagina and did not raise the risk of breast cancer or cardiovascular disease, she said.

And while women who smoked or had high cholesterol, diabetes or hypertension had a slightly increased risk of heart attack and stroke, transdermal hormone therapy might be useful once the risk factors were treated and reduced.

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