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Meals As Medicine: Anti-Obesity Effects Of Soy In Rat Model Of Menopause

Research presented at the Annual Meeting of the Society for the Study of Ingestive Behavior, finds that a diet rich in soy prevents weight gain in post-menopausal female rats.

Previous research suggests that reduced levels of the hormone estrogen during menopause are responsible for the increased body weight and abdominal fat often experienced by postmenopausal women. However, while estrogen replacement therapies can reduce weight gain, they also have unwelcome side effects, prompting a search for alternative methods of treatment.

Soy naturally contains estrogen-like compounds called phytoestrogens, and so dietary soy may provide an alternative to typical estrogen replacement therapies.

Michelle Murphy from the Monell Chemical Senses Center found decreased body weight and increased energy expenditure in post-menopausal rats after adding soy phytoestrogens to their regular diet. She comments, “These results have implications for the development of alternative natural treatments for obesity in post-menopausal women.”

The results of this study highlight the need for further research into the actions of phytoestrogens on food intake in humans to determine the more long-term effects of consuming a soy-rich diet.

“In this world of an ever-increasing obesity epidemic, finding natural dietary solutions and treatments to combat obesity are of the utmost importance both to worldwide health and economy,” says Murphy.

The lead author was Michelle Murphy of the Monell Chemical Senses Center, Philadelphia, PA, USA. Co-authors were MR Rosazza, DR Reed and MG Tordoff also of the Monell Chemical Senses Center, Philadelphia, PA, USA.

Women Hit By Midlife Challenges

It is dubbed the midlife crisis, middle age spread era, the climacteric, the change of life or simply “the change” and has even inspired a play, Menopause the Musical.

The variety of nicknames for menopause reflects the diversity of ways in which women are affected during this major turning point in their life.

Most women have a relatively easy time making their way through menopause, some completely breeze through without a whimper but there are the unfortunate ones who are hit hard by unrelenting symptoms.

Internationally renowned gynaecologist Dr Elizabeth Farrell, who specialises in menopause and is a founding Board member of the Jean Hailes Foundation for Women’s Health in Victoria, said that the majority of women would have mild to moderate symptoms and could probably manage without any added therapy.

About 20 per cent of women would experience no symptoms.

“Their periods will stop and they will feel fit and healthy and nothing will be different,” she said.

Another 20 per cent would have severe symptoms which impacted on their quality of life and were the women who really needed to have treatment.

For women in their perimenopausal and early-postmenopausal years, the use of hormone replacement therapy was considered safe.

“But it is contrary to people’s memories,” Dr Farrell said.

“They still have the study published in 2002 in the forefront of their brains.”

That study, the Women’s Health Initiative, reported a slightly increased risk of stroke, heart disease and thrombosis in women on long-term combined oestrogen and progesterone HRT.

Dr Farrell said that for women going through menopausal symptoms, the use of HRT was acceptable if they had no heart disease risks and were fit and healthy.

Although the WHI study showed that in those women taking oestrogen and progesterone, there was a small increase in the risk of breast cancer after five years of use, Dr Farrell said most of those women had been on HRT before the study. This was because the average age of participants was 63 years.

Women on oestrogen alone had no increased risk of breast cancer after seven years. In community studies, including the Nurses Health Study, there was no increased risk in women on oestrogen alone until after 15-20 years, Dr Farrell said.

Dr Farrell, who is president of the Australasian Menopause Society and also the Asia Pacific Menopause Federation, said it was worth having a medical check to rule out other possible causes – such as high blood pressure and hyper-thyroidism – for hot flashes and sweats.

Although venlafaxine (an antidepressant) could be used to alleviate hot flashes and sweats, it also caused them in about 20-30 per cent of women.

Evidence suggested that women who were suffering from a dry vagina could first try lubricants but if these were not sufficient, they could use one of the vaginal oestrogen products fairly safely, Dr Farrell said.

These included oestriol vaginal creams or pessaries which should be used only about twice a week in the longer term.

Women who wanted to navigate menopause naturally, without any medication, could take certain steps, Dr Farrell said.

Anxiety and stress can be triggers for flushes and sweats. “Some of the things that are recommended are meditation and yoga,” she said.

“Acupuncture hasn’t been shown to be effective but hypnosis has been shown to be effective in some women and things like paced respiration, doing the deep breathing like you do in labour, and biofeedback programs can be helpful.”

Another hazard was a teenage daughter dealing with puberty at the same time her mother was going through menopause. “Sometimes a little bit of family counselling can help,” Dr Farrell said.

Gynaecologist Dr Margaret Smith, who established the first menopause clinic in WA and is a foundation member of the Australasian Menopause Society, said that hormone replacement therapy was now called hormone therapy because the aim was not to attain premenopausal levels of oestrogen but to give small amounts for a short time to ease the symptoms of menopause, such as hot flashes, without causing breast soreness.

But Dr Smith said while some effects of oestrogen deficiency could be relieved, others could last for years. These included loss of bone density, which could lead to osteoporosis, and lack of oestrogens in the vagina which can lead to painful intercourse and urinary tract infection.

Hormone therapy could be given locally into the vagina and did not raise the risk of breast cancer or cardiovascular disease, she said.

And while women who smoked or had high cholesterol, diabetes or hypertension had a slightly increased risk of heart attack and stroke, transdermal hormone therapy might be useful once the risk factors were treated and reduced.

Study Finds Positive Change In Menopausal Experience

White women are becoming more optimistic about menopause, with many seeing it as an opportunity to rethink their lives and redefine themselves, a new University of Texas at Austin national study shows.

This is just one of the positive changes in the way women across different ethnic groups are experiencing the change of life, the School of Nursing research found. The study also found women are getting support from their family and friends and some even mentioned relief and benefits when going through menopause.

Past studies have shown that white women, in particular, were concerned about menopause as a “harbinger of physical aging taking them away from society’s youthful ideal,” said Dr. Eun-Ok Im, the La Quinta Motor Inns Inc. Centennial Professor in nursing. “Most of the white participants in our study say they try to be humorous and laugh — to boost their inner strength and motivate themselves to go through the hardships during the menopausal transition.”

Im’s four-year study, funded by a $1.2 million National Institutes of Health grant, looked at ethnic differences in menopausal symptoms reported by Whites, Hispanics, African American and Asian women. The study was done via a Internet survey among 512 women and included equal numbers of mid-age (40 to 60 years old) participants from each ethnic group.

“A possible reason for the positive changes in the way white women look at menopause might be that the recent women’s health movement has educated women to accept menopause as a normal developmental process, allowing them to refocus on themselves,” said Im.

Results of her research were published recently in the Western Journal of Nursing Research.

African American, Hispanic and Asian women already reported being more optimistic and positive about their menopause and menopause symptoms than white women.

In Im’s study, black participants cited they were raised to be strong and accepting of a natural aging process. They perceived that — compared to other difficulties in their lives — menopause was just another part of life to endure.

Getting support from family and friends during the menopausal transition is especially new to the literature on the menopausal symptom experience of Hispanic women, said Im.

“An interesting new finding, however, is that minority women prefer support from those who are of the same ethnicity,” she said.

Minority participants also expressed their need for more information and educational programs, which Im sees as an additional encouraging sign. In the past, ethnic minority groups rarely talked about menopause with others and hardly ever said they wanted more information about the change of life, she said.

Im’s study supported research that found significant ethnic differences in the total number and severity of menopausal symptoms.

Some of her findings on differences include:

• Black women had a slightly higher percentage of hot flashes at 67.8 percent with white women at 64.4 percent and Hispanic women at 52.5 percent. Only 26.1 percent of Asian Americans said they experienced hot flashes.

• More white women (60 percent) took some kind of treatments for menopause symptoms. These included antidepressants and alternative medicines like herbal remedies, chiropractic, meditation, acupuncture and dietary supplements.

• African American women — 54.6 percent — experienced weight gain compared to 33.3 percent for Asians, 45 percent for white and 50.8 percent for Hispanics.

• Whites reported higher percentages of racing heart, headache, fatigue, sleeping difficulty, breast pain, increased crying, depressed feelings, upset, grouchy feelings, difficulty in concentration, forgetfulness, breathing difficulty, ankle swelling, cold hand and feet, stomach pain, muscle and join stiffness.

• Whites, Hispanics and African Americans reported about the same numbers of bloating while Asians only reported 23.4 percent.

• Whites, Hispanics and African Americans reported about the same percentage of mood swings — above 50 percent — while Asians reported only 32.4 percent mood swing symptoms.

• Asians reported muscle and joint stiffness and neck and skull aches as frequent symptoms of menopause. Findings strongly suggest there are sub-ethnic — Chinese, Korean, Indian Filipino — differences in the menopausal symptom experience of Asians, and more studies are needed in this area.

The research also found few women (in all ethnic groups) reporting positive experiences with their physicians when they consulted them about menopausal symptoms.

Im believes her findings will work to eliminate ethnic biases and inequity in menopausal symptom management and promote culturally competent care for menopausal women. Earlier research about menopause has mostly been with white women, she noted.

“The increasing ethnic diversity of our population requires health professionals to practice with greater cultural competence,” Im said.

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